Immune Tolerance Network   

A clinical research consortium sponsored by NIAID

Benefits & Risks

Weighing the Benefits and Risks of Transplant Therapy

Even though kidney transplant is major surgery with a long recovery period, it can, in comparison to dialysis, offer patients the opportunity for a longer and more satisfying life. Many patients who have been on dialysis and then had a transplant, report having more energy, a less restricted diet, and fewer complications with a transplant than if they had stayed on dialysis.

However, people who have kidney transplants must take anti-rejection medication for the rest of their lives. If they stop, their immune system may reject the transplanted kidney. All anti-rejection medicines have side effects. Because of these side effects, an important goal of transplant research is to allow people to accept their transplanted organ without long-term use of anti-rejection medicines. This is called tolerance.

The RESTARRT trial will test whether experimental therapy can achieve tolerance and will allow patients to discontinue immunosuppressive medications without rejection. This experimental research study will evaluate whether a combination of anti-rejection medicines given before, during, and after transplantation can allow the body to develop tolerance to the transplanted kidney.